Can you believe we first met the ladies of Wisteria Lane 12 years ago? We can't!
To celebrate Desperate Housewives' anniversary, click through the gallery below to see the cast — including Eva Longoria, Felicity Huffman, and more! — then and now!
After Desperate Housewives, Eva appeared on shows Mother Up!, Brooklyn Nine-Nine, and Telenovela.
Nicollette's career calmed down after she left the drama series. She's appeared in a few TV movies as well as Jewtopia and Let's Kill Ward's Wife. She's currently on the show Dynasty.
After Desperate Housewives, Vanessa added 666 Park Avenue, The Good Wife, Milo Murphy's Law, The Librarians, and Daytime Divas to her acting portfolio.
Felicity now stars in the popular TV series American Crime.
Teri has since appeared in series Jane by Design, Jake and the Never Land Pirates, The Odd Couple, and Supergirl.
After Desperate Housewives, Marcia appeared in Law & Order: Special Victims Unit and Quantico.
Brenda has landed roles in Dallas, Blood Relatives, Fear the Walking Dead, and Supergirl following Desperate Housewives.
James has been on Devious Maids and Good Witch since Desperate Housewives.
Ricardo has appeared in Welcome to the Family, Santa Clarita Diet, Jane the Virgin, and Scandal.
Mark has had a very successful career following Desperate Housewives. He's added The Killing, Criminal Minds, Manhattan, Homeland, Mad Men, The Last Ship, Incorporated, Law & Order True Crime, Salvation, Man Seeking Woman, and more to his acting resume.
After Desperate Housewives, Jesse appeared in Chase, Dallas, and Chesapeake Shores.
Steven has since appeared in Grey's Anatomy, Revolution, Code Black, and Bosch.
Doug has made cameos in Drop Dead Diva, Criminal Minds, Hawaii Five-0, The X-Files, and Notorious.
Today, Richard is most known for his portrayal of Paul Hornsby in General Hospital.
Alfre has since appeared in My Own Worst Enemy, Three Rivers, Memphis Beat, True Blood, State of Affairs, Luke Cage, and A Series of Unfortunate Events.
Kyle has appeared in How I Met Your Mother, Believe, Agents of S.H.I.E.L.D., Portlandia, and Twin Peaks.
Dana was seen in Body of Proof, The Comedians, and Hand of God since Desperate Housewives.
Neil has continued his acting career with roles in Mob City, Public Morals, Suits, Arrows, and Legends of Tomorrow.
Drea became well known for her roles in Sons of Anarchy and Shades of Blue following Desperate Housewives.
Kevin has appeared in shows I Hate My Teenage Daughter, Surviving Jack, Mad Men, Bates Motel, Madam Secretary, and now Lethal Weapon.
Tuc is known for his role on the soap opera One Life to Live. He also appeared in Where the Bears Are.
After Desperate Housewives, Jonathan was in Doll & Em, Camping, and The Affair.
Charles has since landed roles in Girlfriends' Guide to Divorce, Dead of Summer, The Magicians, and Once Upon a Time.
Kathryn sadly passed away at age 72 in June 2012 after battling lung cancer.
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